Alpha-bisabolol is a naturally occurring monocyclic sesquiterpene alcohol found in various plants, particularly in the essential oil of chamomile (Matricaria chamomilla or Chamomilla recutita). It is known for its pleasant floral scent and is widely used in the cosmetics and personal care industry due to its various beneficial properties. Here is a comprehensive study of alpha-bisabolol, including its properties, uses, and potential benefits:
1.Chemical Structure and Properties:
Alpha-bisabolol is also known as levomenol or α-bisabolol. Its chemical formula is C15H26O, and it has a molecular weight of 222.37 g/mol. The compound is a clear, colorless to pale yellow liquid at room temperature, with a sweet, floral aroma.
2.Natural Sources:
Alpha-bisabolol is primarily found in the essential oil of chamomile plants. However, it is also present in the oils of other plants, such as Candeia (Eremanthus erythropappus), Vanillosmopsis erythropappa, and some species of the Copaifera genus.
3.Extraction:
Alpha-bisabolol is typically extracted from the essential oil of chamomile through various methods, including steam distillation or solvent extraction.
4.Biological Activities and Benefits:
Alpha-bisabolol possesses several beneficial properties, making it a popular ingredient in cosmetic and personal care products. Some of its notable biological activities include:
a. Anti-inflammatory: Alpha-bisabolol has shown potential in reducing inflammation and soothing irritated skin. This makes it a useful component in skincare products aimed at addressing skin redness, sensitivity, and other inflammatory conditions.
b. Antioxidant: As an antioxidant, alpha-bisabolol can help neutralize harmful free radicals in the skin, which are a major factor in premature aging and skin damage.
c. Anti-microbial: Alpha-bisabolol exhibits antimicrobial activity against certain bacteria and fungi, making it useful for products designed to address skin infections or acne.
d. Wound Healing: Some studies suggest that alpha-bisabolol may promote wound healing by stimulating cell growth and tissue repair processes.
e. Skin Penetration Enhancement: Alpha-bisabolol has been found to enhance the penetration of other active ingredients into the skin, making it a valuable component in transdermal drug delivery systems.
5.Uses in Cosmetics and Personal Care Products:
Alpha-bisabolol is widely used in the cosmetics and personal care industry for various purposes, including:
a. Skincare Products: It is commonly found in moisturizers, lotions, serums, and creams targeting sensitive or irritated skin.
b. Anti-aging Products: Due to its antioxidant properties, alpha-bisabolol is incorporated into products that aim to combat signs of aging, such as fine lines and wrinkles.
c. Sunscreens: Some sunscreen formulations include alpha-bisabolol to help soothe and protect the skin from UV-induced damage.
d. Deodorants: It is used in deodorants and antiperspirants for its pleasant fragrance and potential antimicrobial effects.
e. Hair Care: Alpha-bisabolol is occasionally used in hair care products to improve the condition of the scalp and hair.
6.Safety Considerations:
Alpha-bisabolol is generally considered safe for topical use in cosmetics and personal care products. It is well-tolerated by most individuals and has low allergenic potential. However, it’s essential to perform patch tests before using products containing alpha-bisabolol, especially for individuals with sensitive skin or known allergies.
It’s worth noting that the information provided here is based on knowledge available up to September 2021. For the most current research and findings on alpha-bisabolol, it is advisable to consult the latest scientific literature and reputable sources.