Basic information of Dutasteride

Dutasteride is a medication primarily used to treat benign prostatic hyperplasia (BPH), also known as an enlarged prostate, in men. It is part of a class of drugs called 5-alpha reductase inhibitors, which work by reducing the production of dihydrotestosterone (DHT), a hormone that contributes to prostate growth.

Key Information:

1.Mechanism of Action:

    • Dutasteride inhibits both type I and type II isoenzymes of 5-alpha reductase, which are responsible for converting testosterone into DHT.
    • This reduction in DHT levels helps decrease the size of the prostate and alleviates symptoms of BPH.

    2.Indications:

      • Benign prostatic hyperplasia (BPH): Relieves symptoms like difficulty urinating, frequent urination, and weak stream.
      • Prevention of urinary retention: Reduces the need for surgery related to BPH.
      Basic information of Dutasteride-Xi'an Lyphar Biotech Co., Ltd

      3.Dosage:

        • Commonly prescribed at a dose of 0.5 mg once daily.
        • It is taken orally, with or without food.

        4.Onset of Action:

          • Improvement in symptoms may take several weeks to months, as the prostate shrinks gradually.

          5.Side Effects:

            • Decreased libido.
            • Erectile dysfunction.
            • Ejaculation disorders.
            • Breast tenderness or enlargement.
            • Potential for depression in rare cases.

            6.Precautions:

              • Not for use in women or children.
              • Women who are pregnant or could become pregnant should avoid handling broken or crushed tablets, as the drug can be absorbed through the skin and harm a male fetus.
              • May increase the risk of high-grade prostate cancer, though this is a subject of ongoing research.

              7.Drug Interactions:

                • Can interact with other medications, such as CYP3A4 inhibitors (e.g., ketoconazole, ritonavir), which may increase its levels in the body.
                • Should not be taken with other 5-alpha reductase inhibitors or used in combination with certain alpha-blockers unless recommended by a healthcare provider.
                Basic information of Dutasteride-Xi'an Lyphar Biotech Co., Ltd

                8.Monitoring:

                  • Regular monitoring of prostate-specific antigen (PSA) levels is recommended, as Dutasteride reduces PSA levels, which could mask prostate cancer signs.

                  9.Brand Names:

                    • Commonly sold under brand names like Avodart or generic equivalents.

                    If considering Dutasteride for treatment, consultation with a healthcare professional is essential to ensure its suitability and address potential risks.